diff --git a/pkgs/development/python-modules/rtmidi-python/default.nix b/pkgs/development/python-modules/rtmidi-python/default.nix
index e1565fa6c30c..02bb45fd6bc0 100644
--- a/pkgs/development/python-modules/rtmidi-python/default.nix
+++ b/pkgs/development/python-modules/rtmidi-python/default.nix
@@ -1,4 +1,13 @@
-{ lib, buildPythonPackage, fetchPypi, cython, alsa-lib }:
+{ lib
+, stdenv
+, buildPythonPackage
+, fetchPypi
+, cython
+, alsa-lib
+, CoreAudio
+, CoreMIDI
+, CoreServices
+}:
 
 buildPythonPackage rec {
   pname = "rtmidi-python";
@@ -14,7 +23,13 @@ buildPythonPackage rec {
   '';
 
   nativeBuildInputs = [ cython ];
-  buildInputs = [ alsa-lib ];
+  buildInputs = lib.optionals stdenv.isLinux [
+    alsa-lib
+  ] ++ lib.optionals stdenv.isDarwin [
+    CoreAudio
+    CoreMIDI
+    CoreServices
+  ];
 
   setupPyBuildFlags = [ "--from-cython" ];
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 65704adecf1a..894c218f94be 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8777,7 +8777,9 @@ in {
 
   rstcheck = callPackage ../development/python-modules/rstcheck { };
 
-  rtmidi-python = callPackage ../development/python-modules/rtmidi-python { };
+  rtmidi-python = callPackage ../development/python-modules/rtmidi-python {
+    inherit (pkgs.darwin.apple_sdk.frameworks) CoreAudio CoreMIDI CoreServices;
+  };
 
   rtoml = callPackage ../development/python-modules/rtoml { };