diff --git a/pkgs/development/python-modules/scikit-bio/default.nix b/pkgs/development/python-modules/scikit-bio/default.nix
index 10e635b53b65..151ae1f21f42 100644
--- a/pkgs/development/python-modules/scikit-bio/default.nix
+++ b/pkgs/development/python-modules/scikit-bio/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   fetchFromGitHub,
 
@@ -65,6 +66,10 @@ buildPythonPackage rec {
   # only the $out dir contains the built cython extensions, so we run the tests inside there
   enabledTestPaths = [ "${placeholder "out"}/${python.sitePackages}/skbio" ];
 
+  # The trick above makes test collection fail on darwin:
+  # PermissionError: [Errno 1] Operation not permitted: '/nix/.Trashes'
+  doCheck = !stdenv.hostPlatform.isDarwin;
+
   pythonImportsCheck = [ "skbio" ];
 
   meta = {