diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index ac5d197ab3dd..9a155dd62b48 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -406,9 +406,6 @@ in with passthru; stdenv.mkDerivation (finalAttrs: {
   configureFlags = [
     "--without-ensurepip"
     "--with-system-expat"
-  ] ++ optionals (!(stdenv.isDarwin && pythonAtLeast "3.12")) [
-    #  ./Modules/_decimal/_decimal.c:4673:6: error: "No valid combination of CONFIG_64, CONFIG_32 and _PyHASH_BITS"
-    # https://hydra.nixos.org/build/248410479/nixlog/2/tail
     "--with-system-libmpdec"
   ] ++ optionals (openssl != null) [
     "--with-openssl=${openssl.dev}"
@@ -480,6 +477,10 @@ in with passthru; stdenv.mkDerivation (finalAttrs: {
     export PYTHON_DECIMAL_WITH_MACHINE=${if stdenv.isAarch64 then "uint128" else "x64"}
     # Ensure that modern platform features are enabled on Darwin in spite of having no version suffix.
     sed -E -i -e 's|Darwin/\[12\]\[0-9\]\.\*|Darwin/*|' configure
+  '' + optionalString (pythonAtLeast "3.11") ''
+    # Also override the auto-detection in `configure`.
+    substituteInPlace configure \
+      --replace-fail 'libmpdec_machine=universal' 'libmpdec_machine=${if stdenv.isAarch64 then "uint128" else "x64"}'
   '' + optionalString (stdenv.isDarwin && x11Support && pythonAtLeast "3.11") ''
     export TCLTK_LIBS="-L${tcl}/lib -L${tk}/lib -l${tcl.libPrefix} -l${tk.libPrefix}"
     export TCLTK_CFLAGS="-I${tcl}/include -I${tk}/include"