diff --git a/pkgs/development/python-modules/vllm/default.nix b/pkgs/development/python-modules/vllm/default.nix
index 4797383a3c17..4db1e66064ce 100644
--- a/pkgs/development/python-modules/vllm/default.nix
+++ b/pkgs/development/python-modules/vllm/default.nix
@@ -335,14 +335,14 @@ in
 
 buildPythonPackage.override { stdenv = torch.stdenv; } (finalAttrs: {
   pname = "vllm";
-  version = "0.15.1";
+  version = "0.16.0";
   pyproject = true;
 
   src = fetchFromGitHub {
     owner = "vllm-project";
     repo = "vllm";
     tag = "v${finalAttrs.version}";
-    hash = "sha256-qsAvcOB8ugGlBqBrLfNHqaIUcxLwaXBTg8xWRnGyd94=";
+    hash = "sha256-7E67xVRlKmm+Hbp5nphhwH8SQC9LpCFNBfF2ZAOt79k=";
   };
 
   patches = [
@@ -367,7 +367,8 @@ buildPythonPackage.override { stdenv = torch.stdenv; } (finalAttrs: {
     # pythonRelaxDeps does not cover build-system
     substituteInPlace pyproject.toml \
       --replace-fail "torch ==" "torch >=" \
-      --replace-fail "setuptools>=77.0.3,<81.0.0" "setuptools"
+      --replace-fail "setuptools>=77.0.3,<81.0.0" "setuptools" \
+      --replace-fail "grpcio-tools==1.78.0" "grpcio"
 
     # Ignore the python version check because it hard-codes minor versions and
     # lags behind `ray`'s python interpreter support