diff --git a/pkgs/development/python-modules/Theano/default.nix b/pkgs/development/python-modules/Theano/default.nix
index e279100e9cc6..351f8dc9b711 100644
--- a/pkgs/development/python-modules/Theano/default.nix
+++ b/pkgs/development/python-modules/Theano/default.nix
@@ -8,19 +8,15 @@
 , nose
 , numpy
 , scipy
+, setuptools
 , six
 , libgpuarray
 , cudaSupport ? false, cudatoolkit
 , cudnnSupport ? false, cudnn
-, nvidia_x11
 }:
 
 assert cudnnSupport -> cudaSupport;
 
-assert cudaSupport -> nvidia_x11 != null
-                   && cudatoolkit != null
-                   && cudnn != null;
-
 let
   wrapped = command: buildTop: buildInputs:
     runCommandCC "${command}-wrapped" { inherit buildInputs; } ''
@@ -81,7 +77,15 @@ in buildPythonPackage rec {
 
   # keep Nose around since running the tests by hand is possible from Python or bash
   checkInputs = [ nose ];
-  propagatedBuildInputs = [ numpy numpy.blas scipy six libgpuarray_ ];
+  # setuptools needed for cuda support
+  propagatedBuildInputs = [
+    libgpuarray_
+    numpy
+    numpy.blas
+    scipy
+    setuptools
+    six
+  ];
 
   pythonImportsCheck = [ "theano" ];
 
diff --git a/pkgs/development/python-modules/libgpuarray/default.nix b/pkgs/development/python-modules/libgpuarray/default.nix
index d061356490cb..2be115ae3658 100644
--- a/pkgs/development/python-modules/libgpuarray/default.nix
+++ b/pkgs/development/python-modules/libgpuarray/default.nix
@@ -1,5 +1,6 @@
 { stdenv
 , lib
+, addOpenGLRunpath
 , buildPythonPackage
 , fetchFromGitHub
 , cmake
@@ -8,13 +9,10 @@
 , six
 , nose
 , Mako
-, cudaSupport ? false, cudatoolkit , nvidia_x11
+, cudaSupport ? false, cudatoolkit
 , openclSupport ? true, ocl-icd, clblas
 }:
 
-assert cudaSupport -> nvidia_x11 != null
-                   && cudatoolkit != null;
-
 buildPythonPackage rec {
   pname = "libgpuarray";
   version = "0.7.6";
@@ -32,8 +30,7 @@ buildPythonPackage rec {
   configurePhase = "cmakeConfigurePhase";
 
   libraryPath = lib.makeLibraryPath (
-    []
-    ++ lib.optionals cudaSupport [ cudatoolkit.lib cudatoolkit.out nvidia_x11 ]
+    lib.optionals cudaSupport [ cudatoolkit.lib cudatoolkit.out ]
     ++ lib.optionals openclSupport ([ clblas ] ++ lib.optional (!stdenv.isDarwin) ocl-icd)
   );
 
@@ -55,6 +52,8 @@ buildPythonPackage rec {
     }
 
     fixRunPath $out/lib/libgpuarray.so
+  '' + lib.optionalString cudaSupport ''
+    addOpenGLRunpath $out/lib/libgpuarray.so
   '';
 
   propagatedBuildInputs = [
@@ -63,7 +62,12 @@ buildPythonPackage rec {
     Mako
   ];
 
-  nativeBuildInputs = [ cmake ];
+  nativeBuildInputs = [
+    cmake
+  ] ++ lib.optionals cudaSupport [
+    addOpenGLRunpath
+  ];
+
 
   buildInputs = [
     cython
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f106002fe0cd..f138448c155f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4148,7 +4148,6 @@ in {
   libgpuarray = callPackage ../development/python-modules/libgpuarray {
     clblas = pkgs.clblas.override { boost = self.boost; };
     cudaSupport = pkgs.config.cudaSupport or false;
-    inherit (pkgs.linuxPackages) nvidia_x11;
   };
 
   libiio = (toPythonModule (pkgs.libiio.override { inherit python; })).python;
@@ -8924,7 +8923,6 @@ in {
   Theano = callPackage ../development/python-modules/Theano rec {
     cudaSupport = pkgs.config.cudaSupport or false;
     cudnnSupport = cudaSupport;
-    inherit (pkgs.linuxPackages) nvidia_x11;
   };
 
   TheanoWithCuda = self.Theano.override {