diff --git a/pkgs/development/python-modules/pyreaderwriterlock/default.nix b/pkgs/development/python-modules/pyreaderwriterlock/default.nix
deleted file mode 100644
index 4e5ae15f9f58..000000000000
--- a/pkgs/development/python-modules/pyreaderwriterlock/default.nix
+++ /dev/null
@@ -1,43 +0,0 @@
-{
-  lib,
-  fetchFromGitHub,
-  buildPythonPackage,
-
-  # build-system
-  setuptools,
-
-  # dependencies
-  typing-extensions,
-
-  # tests
-  pytestCheckHook,
-}:
-
-buildPythonPackage rec {
-  pname = "pyreaderwriterlock";
-  version = "1.0.9";
-  pyproject = true;
-
-  src = fetchFromGitHub {
-    owner = "elarivie";
-    repo = "pyReaderWriterLock";
-    tag = "v${version}";
-    hash = "sha256-8FC+4aDgGpF1BmOdlkFtMy7OfWdSmvn9fjKXSmmeJlg=";
-  };
-
-  build-system = [ setuptools ];
-
-  dependencies = [ typing-extensions ];
-
-  nativeCheckInputs = [ pytestCheckHook ];
-
-  pythonImportsCheck = [ "readerwriterlock" ];
-
-  meta = {
-    changelog = "https://github.com/elarivie/pyReaderWriterLock/blob/master/CHANGELOG.md";
-    description = "Implementation of the Readers-writers problem";
-    homepage = "https://github.com/elarivie/pyReaderWriterLock";
-    license = lib.licenses.mit;
-    maintainers = with lib.maintainers; [ MayNiklas ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index bc608662054a..223f597fd1d0 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -420,6 +420,7 @@ mapAliases {
   pyramid_mako = throw "'pyramid_mako' has been renamed to/replaced by 'pyramid-mako'"; # Converted to throw 2025-10-29
   pyramid_multiauth = throw "'pyramid_multiauth' has been renamed to/replaced by 'pyramid-multiauth'"; # Converted to throw 2025-10-29
   pyreadability = throw "'pyreadability' has been renamed to/replaced by 'readability-lxml'"; # Converted to throw 2025-10-29
+  pyreaderwriterlock = throw "'pyreaderwriterlock' has been removed as it was unmaintained upstream"; # Added 2026-03-21
   pyRFC3339 = throw "'pyRFC3339' has been renamed to/replaced by 'pyrfc3339'"; # Converted to throw 2025-10-29
   Pyro4 = throw "'Pyro4' has been renamed to/replaced by 'pyro4'"; # Converted to throw 2025-10-29
   Pyro5 = throw "'Pyro5' has been renamed to/replaced by 'pyro5'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3d3e41efffa5..8377b61ef6b6 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -14757,8 +14757,6 @@ self: super: with self; {
 
   pyre-extensions = callPackage ../development/python-modules/pyre-extensions { };
 
-  pyreaderwriterlock = callPackage ../development/python-modules/pyreaderwriterlock { };
-
   pyreadstat = callPackage ../development/python-modules/pyreadstat { };
 
   pyrealsense2 = toPythonModule (