diff --git a/pkgs/by-name/ea/easel/package.nix b/pkgs/by-name/ea/easel/package.nix
new file mode 100644
index 000000000000..d172f891eb69
--- /dev/null
+++ b/pkgs/by-name/ea/easel/package.nix
@@ -0,0 +1,49 @@
+{
+  lib,
+  stdenv,
+  fetchFromGitHub,
+  autoreconfHook,
+  perl,
+  python3,
+  versionCheckHook,
+}:
+
+stdenv.mkDerivation (finalAttrs: {
+  pname = "easel";
+  version = "0.49";
+
+  src = fetchFromGitHub {
+    owner = "EddyRivasLab";
+    repo = "easel";
+    tag = "easel-${finalAttrs.version}";
+    hash = "sha256-NSKy7ptNYR0K/VFJNv+5TGWdC1ZM4Y5i/3L+3Coj/sg=";
+  };
+
+  nativeBuildInputs = [ autoreconfHook ];
+
+  enableParallelBuilding = true;
+
+  doCheck = true;
+
+  nativeCheckInputs = [
+    perl
+    python3
+  ];
+
+  preCheck = ''
+    patchShebangs devkit/sqc
+  '';
+
+  doInstallCheck = true;
+
+  nativeInstallCheckInputs = [ versionCheckHook ];
+
+  meta = {
+    description = "Sequence analysis library used by Eddy/Rivas lab code";
+    homepage = "https://github.com/EddyRivasLab/easel";
+    license = lib.licenses.bsd2;
+    mainProgram = "easel";
+    maintainers = with lib.maintainers; [ natsukium ];
+    platforms = lib.platforms.unix;
+  };
+})