diff --git a/pkgs/development/python-modules/python-openzwave/cython.patch b/pkgs/development/python-modules/python-openzwave/cython.patch
deleted file mode 100644
index e01ffdbdc0d0..000000000000
--- a/pkgs/development/python-modules/python-openzwave/cython.patch
+++ /dev/null
@@ -1,20 +0,0 @@
-diff --git a/pyozw_setup.py b/pyozw_setup.py
-index b201840..37bf2a8 100644
---- a/pyozw_setup.py
-+++ b/pyozw_setup.py
-@@ -257,13 +257,13 @@ class Template(object):
-         if sys.platform.startswith("win"):
-             return ['Cython']
-         else:
--            return ['Cython==0.28.6']
-+            return ['Cython>=0.28.6']
- 
-     def build_requires(self):
-         if sys.platform.startswith("win"):
-             return ['Cython']
-         else:
--            return ['Cython==0.28.6']
-+            return ['Cython>=0.28.6']
- 
-     def build(self):
-         if len(self.ctx['extra_objects']) == 1 and os.path.isfile(self.ctx['extra_objects'][0]):
diff --git a/pkgs/development/python-modules/python-openzwave/default.nix b/pkgs/development/python-modules/python-openzwave/default.nix
deleted file mode 100644
index 162fc0fb4c3f..000000000000
--- a/pkgs/development/python-modules/python-openzwave/default.nix
+++ /dev/null
@@ -1,63 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-  isPy3k,
-  pkg-config,
-  libyaml,
-  openzwave,
-  cython,
-  pyserial,
-  six,
-  pydispatcher,
-  urwid,
-}:
-
-buildPythonPackage rec {
-  pname = "python-openzwave";
-  version = "0.4.19";
-  format = "setuptools";
-
-  disabled = !isPy3k;
-
-  src = fetchPypi {
-    pname = "python_openzwave";
-    inherit version;
-    sha256 = "6b40c7711383eeb3535cf5504f1cf47cc1ac7018eb820f299642a5a2795aef84";
-    extension = "zip";
-  };
-
-  nativeBuildInputs = [ pkg-config ];
-  buildInputs = [
-    libyaml
-    openzwave
-    cython
-  ];
-  propagatedBuildInputs = [
-    six
-    urwid
-    pydispatcher
-    pyserial
-  ];
-
-  # primary location for the .xml files is in /etc/openzwave so we override the
-  # /usr/local/etc lookup instead as that allows us to dump new .xml files into
-  # /etc/openzwave if needed
-  postPatch = ''
-    substituteInPlace src-lib/libopenzwave/libopenzwave.pyx \
-      --replace /usr/local/etc/openzwave ${openzwave}/etc/openzwave
-  '';
-
-  patches = [ ./cython.patch ];
-
-  # no tests available
-  doCheck = false;
-
-  meta = {
-    description = "Python wrapper for the OpenZWave C++ library";
-    homepage = "https://github.com/OpenZWave/python-openzwave";
-    license = lib.licenses.gpl3Plus;
-    maintainers = [ ];
-    inherit (openzwave.meta) platforms;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index bf06b3138e97..517adf568d47 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -480,6 +480,7 @@ mapAliases {
   python-Levenshtein = throw "'python-Levenshtein' has been renamed to/replaced by 'levenshtein'"; # Converted to throw 2025-10-29
   python-lz4 = throw "'python-lz4' has been renamed to/replaced by 'lz4'"; # Converted to throw 2025-10-29
   python-mbedtls = throw "'python-mbedtls' has been removed as it is unmaintained";
+  python-openzwave = throw "python-openzwave was removed because openzwave is no longer maintained upstream. Consider using python3Packages.zwave-js-server-python"; # Added 2026-05-14
   python-qt = throw "python-qt has been removed, because hard to maintain and not required by anything"; # Added 2025-01-14
   python-simple-hipchat = throw "'python-simple-hipchat' has been removed because it was broken and unmaintained"; # added 2025-08-26
   python-subunit = throw "'python-subunit' has been renamed to/replaced by 'subunit'"; # Converted to throw 2025-10-29
@@ -489,7 +490,7 @@ mapAliases {
   python_fedora = throw "'python_fedora' has been renamed to/replaced by 'python-fedora'"; # Converted to throw 2025-10-29
   python_magic = throw "'python_magic' has been renamed to/replaced by 'python-magic'"; # Converted to throw 2025-10-29
   python_mimeparse = throw "'python_mimeparse' has been renamed to/replaced by 'python-mimeparse'"; # Converted to throw 2025-10-29
-  python_openzwave = throw "'python_openzwave' has been renamed to/replaced by 'python-openzwave'"; # Converted to throw 2025-10-29
+  python_openzwave = throw "python-openzwave was removed because openzwave is no longer maintained upstream. Consider using python3Packages.zwave-js-server-python"; # Converted to throw 2025-10-29
   python_simple_hipchat = throw "'python_simple_hipchat' has been renamed to/replaced by 'python-simple-hipchat'"; # Converted to throw 2025-10-29
   pythonix = throw "pythonix was removed as it was unmaintained since 2022"; # added 2025-07-24
   pytorch = throw "'pytorch' has been renamed to/replaced by 'torch'"; # Converted to throw 2025-10-29
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 93360c36724f..1b0154130a67 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -16019,8 +16019,6 @@ self: super: with self; {
 
   python-openstackclient = callPackage ../development/python-modules/python-openstackclient { };
 
-  python-openzwave = callPackage ../development/python-modules/python-openzwave { };
-
   python-osc = callPackage ../development/python-modules/python-osc { };
 
   python-otbr-api = callPackage ../development/python-modules/python-otbr-api { };