diff --git a/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml b/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
index 2542f5762fcc..d5cc14a3bdfd 100644
--- a/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
+++ b/nixos/doc/manual/from_md/release-notes/rl-2211.section.xml
@@ -130,6 +130,15 @@
           PHP now defaults to PHP 8.1, updated from 8.0.
         </para>
       </listitem>
+      <listitem>
+        <para>
+          PHP is now built <literal>NTS</literal> (Non-Thread Safe)
+          style by default, for Apache and <literal>mod_php</literal>
+          usage we still enable <literal>ZTS</literal> (Zend Thread
+          Safe). This has been a common practice for a long time in
+          other distributions.
+        </para>
+      </listitem>
       <listitem>
         <para>
           <literal>protonup</literal> has been aliased to and replaced
diff --git a/nixos/doc/manual/release-notes/rl-2211.section.md b/nixos/doc/manual/release-notes/rl-2211.section.md
index c4bc7e7db09b..d61cf2967553 100644
--- a/nixos/doc/manual/release-notes/rl-2211.section.md
+++ b/nixos/doc/manual/release-notes/rl-2211.section.md
@@ -53,6 +53,10 @@ In addition to numerous new and upgraded packages, this release has the followin
 
 - PHP now defaults to PHP 8.1, updated from 8.0.
 
+- PHP is now built `NTS` (Non-Thread Safe) style by default, for Apache and
+  `mod_php` usage we still enable `ZTS` (Zend Thread Safe). This has been a
+  common practice for a long time in other distributions.
+
 - `protonup` has been aliased to and replaced by `protonup-ng` due to upstream not maintaining it.
 
 - Perl has been updated to 5.36, and its core module `HTTP::Tiny` was patched to verify SSL/TLS certificates by default.
diff --git a/nixos/modules/services/web-servers/apache-httpd/default.nix b/nixos/modules/services/web-servers/apache-httpd/default.nix
index 3ccff8aa5008..588f5ee4d003 100644
--- a/nixos/modules/services/web-servers/apache-httpd/default.nix
+++ b/nixos/modules/services/web-servers/apache-httpd/default.nix
@@ -18,7 +18,7 @@ let
     sed -i $out/bin/apachectl -e 's|$HTTPD -t|$HTTPD -t -f /etc/httpd/httpd.conf|'
   '';
 
-  php = cfg.phpPackage.override { apacheHttpd = pkg; };
+  php = cfg.phpPackage.override { apxs2Support = true; apacheHttpd = pkg; };
 
   phpModuleName = let
     majorVersion = lib.versions.major (lib.getVersion php);
@@ -660,6 +660,13 @@ in
           `services.httpd.virtualHosts.<name>.useACMEHost` are mutually exclusive.
         '';
       }
+      {
+        assertion = cfg.enablePHP -> php.ztsSupport;
+        message = ''
+          The php package provided by `services.httpd.phpPackage` is not built with zts support. Please
+          ensure the php has zts support by settings `services.httpd.phpPackage = php.override { ztsSupport = true; }`
+        '';
+      }
     ] ++ map (name: mkCertOwnershipAssertion {
       inherit (cfg) group user;
       cert = config.security.acme.certs.${name};
diff --git a/pkgs/development/interpreters/php/generic.nix b/pkgs/development/interpreters/php/generic.nix
index d1b7c6829557..e252e011105e 100644
--- a/pkgs/development/interpreters/php/generic.nix
+++ b/pkgs/development/interpreters/php/generic.nix
@@ -43,7 +43,7 @@ let
     , phpdbgSupport ? true
 
       # Misc flags
-    , apxs2Support ? !stdenv.isDarwin
+    , apxs2Support ? false
     , argon2Support ? true
     , cgotoSupport ? false
     , embedSupport ? false