diff --git a/pkgs/development/node-packages/aliases.nix b/pkgs/development/node-packages/aliases.nix
index 4679a9e3b4ac..8002736da157 100644
--- a/pkgs/development/node-packages/aliases.nix
+++ b/pkgs/development/node-packages/aliases.nix
@@ -329,6 +329,7 @@ mapAliases {
   thelounge-theme-zenburn-sourcecodepro = throw "thelounge-theme-zenburn-sourcecodepro has been removed because thelounge was moved out of nodePackages"; # added 2025-03-12
   three = throw "three was removed because it was no longer needed"; # Added 2023-09-08
   triton = pkgs.triton; # Added 2023-05-06
+  ts-node = throw "'ts-node' was removed because it is unmaintained, and since NodeJS 22.6.0+, experimental TypeScript support is built-in to NodeJS."; # Added 2025-11-07
   typescript = pkgs.typescript; # Added 2023-06-21
   inherit (pkgs) typescript-language-server; # added 2024-02-27
   inherit (pkgs) uglify-js; # added 2024-06-15
diff --git a/pkgs/development/node-packages/node-packages.json b/pkgs/development/node-packages/node-packages.json
index 498da824ee90..6803fe32bf9b 100644
--- a/pkgs/development/node-packages/node-packages.json
+++ b/pkgs/development/node-packages/node-packages.json
@@ -81,7 +81,6 @@
 , "svelte-check"
 , "tiddlywiki"
 , "tsun"
-, "ts-node"
 , "ttf2eot"
 , "vega-cli"
 , "vercel"
diff --git a/pkgs/development/node-packages/node-packages.nix b/pkgs/development/node-packages/node-packages.nix
index fc39b02ff2f9..27f3fb47e91c 100644
--- a/pkgs/development/node-packages/node-packages.nix
+++ b/pkgs/development/node-packages/node-packages.nix
@@ -41242,51 +41242,6 @@ in
     bypassCache = true;
     reconstructLock = true;
   };
-  ts-node = nodeEnv.buildNodePackage {
-    name = "ts-node";
-    packageName = "ts-node";
-    version = "10.9.2";
-    src = fetchurl {
-      url = "https://registry.npmjs.org/ts-node/-/ts-node-10.9.2.tgz";
-      sha512 = "f0FFpIdcHgn8zcPSbf1dRevwt047YMnaiJM3u2w2RewrB+fob/zePZcrOyQoLMMO7aBIddLcQIEK5dYjkLnGrQ==";
-    };
-    dependencies = [
-      sources."@cspotcode/source-map-support-0.8.1"
-      sources."@jridgewell/resolve-uri-3.1.2"
-      sources."@jridgewell/sourcemap-codec-1.5.0"
-      sources."@jridgewell/trace-mapping-0.3.9"
-      sources."@swc/core-1.11.9"
-      sources."@swc/counter-0.1.3"
-      sources."@swc/helpers-0.5.15"
-      sources."@swc/types-0.1.19"
-      sources."@swc/wasm-1.11.9"
-      sources."@tsconfig/node10-1.0.11"
-      sources."@tsconfig/node12-1.0.11"
-      sources."@tsconfig/node14-1.0.3"
-      sources."@tsconfig/node16-1.0.4"
-      sources."@types/node-22.13.10"
-      sources."acorn-8.14.1"
-      sources."acorn-walk-8.3.4"
-      sources."arg-4.1.3"
-      sources."create-require-1.1.1"
-      sources."diff-4.0.2"
-      sources."make-error-1.3.6"
-      sources."tslib-2.8.1"
-      sources."typescript-5.8.2"
-      sources."undici-types-6.20.0"
-      sources."v8-compile-cache-lib-3.0.1"
-      sources."yn-3.1.1"
-    ];
-    buildInputs = globalBuildInputs;
-    meta = {
-      description = "TypeScript execution environment and REPL for node.js, with source map support";
-      homepage = "https://typestrong.org/ts-node";
-      license = "MIT";
-    };
-    production = true;
-    bypassCache = true;
-    reconstructLock = true;
-  };
   ttf2eot = nodeEnv.buildNodePackage {
     name = "ttf2eot";
     packageName = "ttf2eot";
diff --git a/pkgs/development/node-packages/overrides.nix b/pkgs/development/node-packages/overrides.nix
index 501cf9c62b88..2e68dbedfa34 100644
--- a/pkgs/development/node-packages/overrides.nix
+++ b/pkgs/development/node-packages/overrides.nix
@@ -115,14 +115,6 @@ final: prev: {
     name = "rush";
   };
 
-  ts-node = prev.ts-node.override {
-    nativeBuildInputs = [ pkgs.buildPackages.makeWrapper ];
-    postInstall = ''
-      wrapProgram "$out/bin/ts-node" \
-      --prefix NODE_PATH : ${pkgs.typescript}/lib/node_modules
-    '';
-  };
-
   tsun = prev.tsun.override {
     nativeBuildInputs = [ pkgs.buildPackages.makeWrapper ];
     postInstall = ''