diff --git a/pkgs/applications/editors/gnome-builder/default.nix b/pkgs/applications/editors/gnome-builder/default.nix
index d9092b550117..0e2ffe46d208 100644
--- a/pkgs/applications/editors/gnome-builder/default.nix
+++ b/pkgs/applications/editors/gnome-builder/default.nix
@@ -5,6 +5,7 @@
 , appstream-glib
 , desktop-file-utils
 , fetchurl
+, fetchpatch
 , flatpak
 , gnome
 , libgit2-glib
@@ -18,7 +19,7 @@
 , jsonrpc-glib
 , libdazzle
 , libpeas
-, libportal
+, libportal-gtk3
 , libxml2
 , meson
 , ninja
@@ -48,6 +49,15 @@ stdenv.mkDerivation rec {
     sha256 = "4iUPyOnp8gAsRS5ZUNgmhXNNPESAs1Fnq1CKyHAlCeE=";
   };
 
+  patches = [
+    # Fix build with latest libportal
+    # https://gitlab.gnome.org/GNOME/gnome-builder/-/merge_requests/486
+    (fetchpatch {
+      url = "https://gitlab.gnome.org/GNOME/gnome-builder/-/commit/b3bfa0df53a3749c3b73cb6c4bad5cab3fa549a1.patch";
+      sha256 = "B/uCcYavFvOAPhLHZ4MRNENDd6VytILiGYwDZRUSxTE=";
+    })
+  ];
+
   nativeBuildInputs = [
     appstream-glib
     desktop-file-utils
@@ -69,7 +79,7 @@ stdenv.mkDerivation rec {
     glade
     libgit2-glib
     libpeas
-    libportal
+    libportal-gtk3
     vte
     gspell
     gtk3
diff --git a/pkgs/applications/graphics/gcolor3/default.nix b/pkgs/applications/graphics/gcolor3/default.nix
index 2771559416bf..63725b97431b 100644
--- a/pkgs/applications/graphics/gcolor3/default.nix
+++ b/pkgs/applications/graphics/gcolor3/default.nix
@@ -6,7 +6,7 @@
 , pkg-config
 , libxml2
 , gtk3
-, libportal
+, libportal-gtk3
 , wrapGAppsHook
 }:
 
@@ -33,12 +33,16 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     gtk3
-    libportal
+    libportal-gtk3
   ];
 
   postPatch = ''
     chmod +x meson_install.sh # patchShebangs requires executable file
     patchShebangs meson_install.sh
+
+    # https://gitlab.gnome.org/World/gcolor3/merge_requests/151
+    substituteInPlace meson.build --replace "dependency(${"\n"}  'libportal'" "dependency(${"\n"}  'libportal-gtk3'"
+    substituteInPlace src/gcolor3-color-selection.c --replace "libportal/portal-gtk3.h" "libportal-gtk3/portal-gtk3.h"
   '';
 
   meta = with lib; {
diff --git a/pkgs/desktops/gnome/core/eog/default.nix b/pkgs/desktops/gnome/core/eog/default.nix
index 620f7e7d9c13..cdde96ae43b9 100644
--- a/pkgs/desktops/gnome/core/eog/default.nix
+++ b/pkgs/desktops/gnome/core/eog/default.nix
@@ -1,5 +1,6 @@
 { lib, stdenv
 , fetchurl
+, fetchpatch
 , meson
 , ninja
 , gettext
@@ -8,7 +9,7 @@
 , libxml2
 , libjpeg
 , libpeas
-, libportal
+, libportal-gtk3
 , gnome
 , gtk3
 , glib
@@ -35,6 +36,15 @@ stdenv.mkDerivation rec {
     sha256 = "sha256-huG5ujnaz3QiavpFermDtBJTuJ9he/VBOcrQiS0C2Kk=";
   };
 
+  patches = [
+    # Fix build with latest libportal
+    # https://gitlab.gnome.org/GNOME/eog/-/merge_requests/115
+    (fetchpatch {
+      url = "https://gitlab.gnome.org/GNOME/eog/-/commit/a06e6325907e136678b0bbe7058c25d688034afd.patch";
+      sha256 = "ttcsfHubfmIbxA51YLnxXDagLLNutXYmoQyMQ4sHRak=";
+    })
+  ];
+
   nativeBuildInputs = [
     meson
     ninja
@@ -49,7 +59,7 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     libjpeg
-    libportal
+    libportal-gtk3
     gtk3
     gdk-pixbuf
     glib
diff --git a/pkgs/desktops/gnome/core/epiphany/default.nix b/pkgs/desktops/gnome/core/epiphany/default.nix
index 0baab20acec9..eb8caa4f1eff 100644
--- a/pkgs/desktops/gnome/core/epiphany/default.nix
+++ b/pkgs/desktops/gnome/core/epiphany/default.nix
@@ -12,7 +12,7 @@
 , wrapGAppsHook
 , gnome
 , pantheon
-, libportal
+, libportal-gtk3
 , libxml2
 , libxslt
 , itstool
@@ -65,6 +65,13 @@ stdenv.mkDerivation rec {
       url = "https://raw.githubusercontent.com/elementary/browser/cc17559a7ac6effe593712b4f3d0bbefde6e3b62/navigation-buttons.patch";
       sha256 = "sha256-G1/JUjn/8DyO9sgL/5Kq205KbTOs4EMi4Vf3cJ8FHXU=";
     })
+  ] ++ [
+    # Fix build with latest libportal
+    # https://gitlab.gnome.org/GNOME/epiphany/-/merge_requests/1051
+    (fetchpatch {
+      url = "https://gitlab.gnome.org/GNOME/epiphany/-/commit/84474398f6e59266b73170838219aa896729ce93.patch";
+      sha256 = "SeiLTo3FcOxuml5sJX9GqyGdyGf1jm1A76SOI0JJvoo=";
+    })
   ];
 
   nativeBuildInputs = [
@@ -100,7 +107,7 @@ stdenv.mkDerivation rec {
     json-glib
     libdazzle
     libhandy
-    libportal
+    libportal-gtk3
     libnotify
     libarchive
     libsecret
diff --git a/pkgs/desktops/gnome/core/nautilus/default.nix b/pkgs/desktops/gnome/core/nautilus/default.nix
index 4f7df313ad52..3e45e616f4c6 100644
--- a/pkgs/desktops/gnome/core/nautilus/default.nix
+++ b/pkgs/desktops/gnome/core/nautilus/default.nix
@@ -1,5 +1,6 @@
 { lib, stdenv
 , fetchurl
+, fetchpatch
 , meson
 , ninja
 , pkg-config
@@ -10,7 +11,7 @@
 , wrapGAppsHook
 , gtk3
 , libhandy
-, libportal
+, libportal-gtk3
 , gnome
 , gnome-autoar
 , glib-networking
@@ -52,6 +53,17 @@ stdenv.mkDerivation rec {
       src = ./fix-paths.patch;
       inherit tracker;
     })
+
+    # Fix build with latest libportal
+    # https://gitlab.gnome.org/GNOME/nautilus/-/merge_requests/749
+    (fetchpatch {
+      url = "https://gitlab.gnome.org/GNOME/nautilus/-/commit/55cfd66ccca391fc144f5863ff6bfc1f3b137e2d.patch";
+      sha256 = "xSb9l7xxEYpAwmdmeWT/t7Z9Ck3DPtsODzbReQW/Q70=";
+      excludes = [
+        "build-aux/flatpak/org.gnome.Nautilus.json"
+        "build-aux/flatpak/org.gnome.Nautilus.yml"
+      ];
+    })
   ];
 
   nativeBuildInputs = [
@@ -76,7 +88,7 @@ stdenv.mkDerivation rec {
     gst_all_1.gst-plugins-base
     gtk3
     libhandy
-    libportal
+    libportal-gtk3
     libexif
     libnotify
     libseccomp