diff --git a/pkgs/development/ocaml-modules/gluon/default.nix b/pkgs/development/ocaml-modules/gluon/default.nix
index 38feb97ba896..9bc4408c28ab 100644
--- a/pkgs/development/ocaml-modules/gluon/default.nix
+++ b/pkgs/development/ocaml-modules/gluon/default.nix
@@ -2,6 +2,7 @@
   lib,
   buildDunePackage,
   fetchurl,
+  fetchpatch,
   bytestring,
   config,
   libc,
@@ -20,6 +21,11 @@ buildDunePackage rec {
     hash = "sha256-YWJCPokY1A7TGqCGoxJl14oKDVeMNybEEB7KiK92WSo=";
   };
 
+  patches = fetchpatch {
+    url = "https://github.com/riot-ml/gluon/commit/b29c34d04ea05d7721a229c35132320e796ed4b2.patch";
+    hash = "sha256-XuzyoteQAgEs93WrgHTWT1I+hIJAiGiJ4XAiLtnEYtw=";
+  };
+
   buildInputs = [
     config
   ];
diff --git a/pkgs/development/ocaml-modules/janestreet/0.17.nix b/pkgs/development/ocaml-modules/janestreet/0.17.nix
index 404dfd614fbd..8e43fde337bf 100644
--- a/pkgs/development/ocaml-modules/janestreet/0.17.nix
+++ b/pkgs/development/ocaml-modules/janestreet/0.17.nix
@@ -1,6 +1,7 @@
 {
   self,
   bash,
+  fetchpatch,
   fzf,
   lib,
   openssl,
@@ -211,6 +212,10 @@ with self;
       ctypes-foreign
       openssl
     ];
+    patches = fetchpatch {
+      url = "https://raw.githubusercontent.com/ocaml/opam-source-archives/main/patches/async_ssl/no-incompatible-pointer-types-017.patch";
+      hash = "sha256-bpfIi97/b1hIwsFzsmhFAZV1w8CdaMxXoi72ScSYMjY=";
+    };
   };
 
   async_unix = janePackage {
@@ -498,6 +503,13 @@ with self;
       patchShebangs unix_pseudo_terminal/src/discover.sh
     '';
     doCheck = false; # command_validate_parsing.exe is not specified in test build deps
+
+    # Compatibility with OCaml 5.3
+    patches = lib.optional (lib.versionAtLeast ocaml.version "5.3") (fetchpatch {
+      url = "https://github.com/janestreet/core_unix/commit/ebce389ac68e098f542e34400e114ac992f415af.patch";
+      includes = [ "bigstring_unix/src/bigstring_unix_stubs.c" ];
+      hash = "sha256-FGg2zlyp3aZFu1VeFdm7pgSPiW0HAkLYgMGTj+tqju8=";
+    });
   };
 
   csvfields = janePackage {
@@ -1545,8 +1557,8 @@ with self;
     // (
       if lib.versionAtLeast ocaml.version "5.3" then
         {
-          version = "0.17.1";
-          hash = "sha256-kcGXqO1kFYds8KwLvpIQ7OKhqnp6JZs8WYYLi7o/nBw=";
+          version = "0.17.2";
+          hash = "sha256-AQJSdKtF6p/aG5Lx8VHVEOsisH8ep+iiml6DtW+Hdik=";
         }
       else
         {
diff --git a/pkgs/development/ocaml-modules/labltk/default.nix b/pkgs/development/ocaml-modules/labltk/default.nix
index b7e00aec4908..2ec6bc0e9d5c 100644
--- a/pkgs/development/ocaml-modules/labltk/default.nix
+++ b/pkgs/development/ocaml-modules/labltk/default.nix
@@ -78,6 +78,10 @@ let
         version = "8.06.14";
         sha256 = "sha256-eVSQetk+i3KObjHfsvnD615cIsq3aZ7IxycX42cuPIU=";
       };
+      "5.3" = mkNewParam {
+        version = "8.06.15";
+        sha256 = "sha256-I/y5qr5sasCtlrwxL/Lex79rg0o4tzDMBmQY7MdpU2w=";
+      };
     };
   param =
     params.${lib.versions.majorMinor ocaml.version}
diff --git a/pkgs/development/ocaml-modules/ocaml-lsp/jsonrpc.nix b/pkgs/development/ocaml-modules/ocaml-lsp/jsonrpc.nix
index aa90b9ac91f3..451b9e7f0d88 100644
--- a/pkgs/development/ocaml-modules/ocaml-lsp/jsonrpc.nix
+++ b/pkgs/development/ocaml-modules/ocaml-lsp/jsonrpc.nix
@@ -9,7 +9,9 @@
   lib,
   ocaml,
   version ?
-    if lib.versionAtLeast ocaml.version "5.2" then
+    if lib.versionAtLeast ocaml.version "5.3" then
+      "1.22.0"
+    else if lib.versionAtLeast ocaml.version "5.2" then
       "1.21.0"
     else if lib.versionAtLeast ocaml.version "4.14" then
       "1.18.0"
@@ -24,6 +26,11 @@
 let
   params =
     {
+      "1.22.0" = {
+        name = "lsp";
+        minimalOCamlVersion = "5.2";
+        sha256 = "sha256-UZ3DV30V3CIQ3vpYBIGnQ1eRGNUGk7aRuxDLyCA/tYE=";
+      };
       "1.21.0" = {
         name = "lsp";
         minimalOCamlVersion = "5.2";
diff --git a/pkgs/development/ocaml-modules/ocaml-lsp/lsp.nix b/pkgs/development/ocaml-modules/ocaml-lsp/lsp.nix
index e05c0494515f..d9c5df1c63f5 100644
--- a/pkgs/development/ocaml-modules/ocaml-lsp/lsp.nix
+++ b/pkgs/development/ocaml-modules/ocaml-lsp/lsp.nix
@@ -23,7 +23,9 @@
   ocamlformat-rpc-lib,
   ocaml,
   version ?
-    if lib.versionAtLeast ocaml.version "5.2" then
+    if lib.versionAtLeast ocaml.version "5.3" then
+      "1.22.0"
+    else if lib.versionAtLeast ocaml.version "5.2" then
       "1.21.0"
     else if lib.versionAtLeast ocaml.version "4.14" then
       "1.18.0"
diff --git a/pkgs/development/ocaml-modules/secp256k1/default.nix b/pkgs/development/ocaml-modules/secp256k1/default.nix
index 5a97578db5dd..d27d260a3723 100644
--- a/pkgs/development/ocaml-modules/secp256k1/default.nix
+++ b/pkgs/development/ocaml-modules/secp256k1/default.nix
@@ -1,6 +1,7 @@
 {
   lib,
   fetchFromGitHub,
+  fetchpatch,
   buildDunePackage,
   base,
   stdio,
@@ -21,6 +22,11 @@ buildDunePackage rec {
     hash = "sha256-22+dZb3MC1W5Qvsz3+IHV1/XiGCRmJHTH+6IW2QX2hU=";
   };
 
+  patches = fetchpatch {
+    url = "https://github.com/dakk/secp256k1-ml/commit/9bde90a401746dcecdab68a2fdb95659d16a3022.patch";
+    hash = "sha256-QndtZJtPKPjuv84jDmXc9Q/xGLb/mNUGL4AvRecSFlQ=";
+  };
+
   buildInputs = [
     base
     stdio
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index 4c0fd36e7923..9bf25691de76 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -793,7 +793,7 @@ let
       then import ../development/ocaml-modules/janestreet/0.17.nix
          {
            inherit self;
-           inherit (pkgs) bash fzf lib openssl zstd;
+           inherit (pkgs) bash fetchpatch fzf lib openssl zstd;
          }
       else if lib.versionOlder "4.13.1" ocaml.version
       then import ../development/ocaml-modules/janestreet/0.16.nix {