diff --git a/pkgs/development/python-modules/curve25519-donna/default.nix b/pkgs/development/python-modules/curve25519-donna/default.nix
deleted file mode 100644
index 8ff358be6905..000000000000
--- a/pkgs/development/python-modules/curve25519-donna/default.nix
+++ /dev/null
@@ -1,23 +0,0 @@
-{
-  lib,
-  buildPythonPackage,
-  fetchPypi,
-}:
-
-buildPythonPackage rec {
-  pname = "curve25519-donna";
-  version = "1.3";
-  format = "setuptools";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "1w0vkjyh4ki9n98lr2hg09f1lr1g3pz48kshrlic01ba6pasj60q";
-  };
-
-  meta = with lib; {
-    description = "Python wrapper for the portable curve25519-donna implementation";
-    homepage = "http://code.google.com/p/curve25519-donna/";
-    license = licenses.bsd3;
-    maintainers = [ ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 7bdfd480f5c8..5b122767add3 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -166,6 +166,7 @@ mapAliases ({
   cryptacular = throw "cryptacular was removed, because it was disabled on all python version since 3.6 and last updated in 2021"; # Added 2024-05-13
   cryptography_vectors = "cryptography_vectors is no longer exposed in python*Packages because it is used for testing cryptography only."; # Added 2022-03-23
   cufflinks = throw "cufflinks has removed, since it is abandoned and broken"; # added 2025-02-16
+  curve25519-donna = throw "unused leaf package with dead upstream repository and no release in 10 years"; # added 2025-05-21
   cx_Freeze = cx-freeze; # added 2023-08-02
   cx_oracle = cx-oracle; # added 2024-01-03
   d2to1 = throw "d2to1 is archived and no longer works with setuptools v68"; # added 2023-07-30
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index c553b0ecd39a..9fe1af33c0d8 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3060,8 +3060,6 @@ self: super: with self; {
 
   curtsies = callPackage ../development/python-modules/curtsies { };
 
-  curve25519-donna = callPackage ../development/python-modules/curve25519-donna { };
-
   curvefitgui = callPackage ../development/python-modules/curvefitgui { };
 
   customtkinter = callPackage ../development/python-modules/customtkinter { };