diff --git a/pkgs/tools/misc/ntfy/default.nix b/pkgs/tools/misc/ntfy/default.nix
index c79ca23e1b5e..a37df5d36377 100644
--- a/pkgs/tools/misc/ntfy/default.nix
+++ b/pkgs/tools/misc/ntfy/default.nix
@@ -1,10 +1,10 @@
 {
   lib,
   stdenv,
-  python39,
+  python3,
   fetchFromGitHub,
   fetchpatch,
-  withXmpp ? !stdenv.hostPlatform.isDarwin,
+  withXmpp ? false, # sleekxmpp doesn't support python 3.10, see https://github.com/dschep/ntfy/issues/266
   withMatrix ? true,
   withSlack ? true,
   withEmoji ? true,
@@ -13,15 +13,13 @@
 }:
 
 let
-  python = python39.override {
+  python = python3.override {
     self = python;
     packageOverrides = self: super: {
       ntfy-webpush = self.callPackage ./webpush.nix { };
 
       # databases, on which slack-sdk depends, is incompatible with SQLAlchemy 2.0
       sqlalchemy = super.sqlalchemy_1_4;
-
-      django = super.django_3;
     };
   };
 in
@@ -38,11 +36,47 @@ python.pkgs.buildPythonApplication rec {
     sha256 = "09f02cn4i1l2aksb3azwfb70axqhn7d0d0vl2r6640hqr74nc1cv";
   };
 
-  nativeCheckInputs = with python.pkgs; [
-    mock
+  patches = [
+    # Fix Slack integration no longer working.
+    # From https://github.com/dschep/ntfy/pull/229 - "Swap Slacker for Slack SDK"
+    (fetchpatch {
+      name = "ntfy-Swap-Slacker-for-Slack-SDK.patch";
+      url = "https://github.com/dschep/ntfy/commit/2346e7cfdca84c8f1afc7462a92145c1789deb3e.patch";
+      sha256 = "13k7jbsdx0jx7l5s8whirric76hml5bznkfcxab5xdp88q52kpk7";
+    })
+    # Add compatibility with emoji 2.0
+    # https://github.com/dschep/ntfy/pull/250
+    (fetchpatch {
+      name = "ntfy-Add-compatibility-with-emoji-2.0.patch";
+      url = "https://github.com/dschep/ntfy/commit/4128942bb7a706117e7154a50a73b88f531631fe.patch";
+      sha256 = "sha256-V8dIy/K957CPFQQS1trSI3gZOjOcVNQLgdWY7g17bRw=";
+    })
+    # Change getargspec to getfullargspec for python 3.11 compatibility
+    (fetchpatch {
+      url = "https://github.com/dschep/ntfy/commit/71be9766ea041d2df6ebbce2781f980eea002852.patch";
+      hash = "sha256-6OChaTj4g3gxVDScc/JksBISHuq+5fbNQregchSXYaQ=";
+    })
+    # Fix compatibility with Python 3.11
+    # https://github.com/dschep/ntfy/pull/271
+    (fetchpatch {
+      url = "https://github.com/dschep/ntfy/pull/271/commits/444b60bec7de474d029cac184e82885011dd1474.patch";
+      hash = "sha256-PKTu8cOpws1z6f1T4uIi2iCJAoAwu+X0Pe7XnHYtHuI=";
+    })
+    # Fix compatibility with Python 3.12
+    # https://github.com/dschep/ntfy/pull/271
+    (fetchpatch {
+      url = "https://github.com/dschep/ntfy/pull/271/commits/d49ab9f9dba4966a44b5f0c6911741edabd35f6b.patch";
+      hash = "sha256-qTUWMS8EXWYCK/ZL0Us7iJp62UIKwYT1BqDy59832ig=";
+    })
   ];
 
-  propagatedBuildInputs =
+  postPatch = ''
+    # We disable the Darwin specific things because it relies on pyobjc, which we don't have.
+    substituteInPlace setup.py \
+      --replace "':sys_platform == \"darwin\"'" "'darwin'"
+  '';
+
+  dependencies =
     with python.pkgs;
     (
       [
@@ -72,31 +106,21 @@ python.pkgs.buildPythonApplication rec {
       ])
     );
 
-  patches = [
-    # Fix Slack integration no longer working.
-    # From https://github.com/dschep/ntfy/pull/229 - "Swap Slacker for Slack SDK"
-    (fetchpatch {
-      name = "ntfy-Swap-Slacker-for-Slack-SDK.patch";
-      url = "https://github.com/dschep/ntfy/commit/2346e7cfdca84c8f1afc7462a92145c1789deb3e.patch";
-      sha256 = "13k7jbsdx0jx7l5s8whirric76hml5bznkfcxab5xdp88q52kpk7";
-    })
-    # Add compatibility with emoji 2.0
-    # https://github.com/dschep/ntfy/pull/250
-    (fetchpatch {
-      name = "ntfy-Add-compatibility-with-emoji-2.0.patch";
-      url = "https://github.com/dschep/ntfy/commit/4128942bb7a706117e7154a50a73b88f531631fe.patch";
-      sha256 = "sha256-V8dIy/K957CPFQQS1trSI3gZOjOcVNQLgdWY7g17bRw=";
-    })
+  nativeCheckInputs = with python.pkgs; [
+    mock
+    pytestCheckHook
   ];
 
-  postPatch = ''
-    # We disable the Darwin specific things because it relies on pyobjc, which we don't have.
-    substituteInPlace setup.py \
-      --replace "':sys_platform == \"darwin\"'" "'darwin'"
-  '';
+  disabledTests = [
+    "test_xmpp"
+  ];
 
-  checkPhase = ''
-    HOME=$(mktemp -d) ${python.interpreter} setup.py test
+  disabledTestPaths = [
+    "tests/test_xmpp.py"
+  ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
   '';
 
   meta = with lib; {